Agmatine Sulfate Powder



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Agmatine Sulfate Powder

Agmatine sulfate is a compound derived from the amino acid, L-arginine, which is involved in the synthesis of proteins. When L-arginine undergoes what’s called decarboxylation, a process that results in the removal of a carboxylic acid, it becomes agmatine sulfate. This compound is stored in the neurons of the brain and released when those neurons are activated.

The process of creating and storing agmatine sulfate is what sets it apart from its amino acid counterpart. Agmatine sulfate is considered a “neurotransmitter” or “neuromodulator” As a nootropic, agmatine sulfate offers a wide range of potential benefits to your brain health and general fitness, these include:

Agmatine May Help with Depression and Anxiety

By increasing NRF2, agmatine prevented depressive behavior in rats by protecting brain cells from high levels of the stress hormone cortisol. Agmatine increased adenylate cyclase in the prefrontal cortex of rats. Decreased levels of adenylate cyclase are associated with depression.

Additionally, blocking the NMDA receptor prevents calcium overloading and reverses the decrease of monoamines (such as norepinephrine, epinephrine, and dopamine) in rats. Depression may be associated with a decrease of monoamines in the brain.

In a small pilot study of 3 depressed patients, agmatine supplementation caused a complete disappearance in depressive symptoms in all patients, likely through NMDA receptor-blocking and not through serotonin pathways.

Agmatine also reduced anxiety in rats during swimming tests and navigating mazes.

Agmatine May Improve Recording of Spatial Memory

Agmatine is increased during spatial learning tasks and is stored in high levels in the hippocampus (a region of the brain associated with memory). Its role as a neurotransmitter is associated with memory formation. Agmatine also improved spatial memory consolidation, or the initial recording and storing of memory, but had no effect on the retrieval of memories in rats.

Agmatine increased brain-derived neurotrophic factor (BDNF) in the brains of rats, a molecule that stimulates the production of new brain cells (neurogenesis). Agmatine increased adenylate cyclase activity in the prefrontal cortex of rats, a molecule associated with memory formation.

Agmatine May Protect Against Stress

Agmatine significantly reduced high body temperature from prolonged heat stress and fever in mice caused by bacterial toxins called lipopolysaccharides (LPS). Agmatine also increased the survival rate of mice exposed to LPS.


Agmatine Dosage

There is currently no standard dosage for agmatine sulfate because there haven’t been enough human studies for determination. These numbers are rough estimates to give an idea of typical, experimental dosing:

  • For the treatment of neuropathic pain: 1,000 to 2,500 mg of agmatine (daily)
  • To improve cognitive function: 200 to 500 mg of agmatine (daily)
  • For vasodilation and enhanced recovery: 500 to 1,000 mg of agmatine (30 minutes pre-workout)

Where to buy Agmatine Sulfate Powder

Nootropic Source offers 125g or 250g jars of high-quality Agmatine sulfate powder. Nootropics Depot’s Agmatine sulfate has been lab-tested and verified for both product purity and identity.


Weight 0.025 kg
Dimensions 17 × 2 × 14 cm



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